Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol

Cancer Lett. 1998 Dec 25;134(2):163-8. doi: 10.1016/s0304-3835(98)00253-5.


[6]-Gingerol, a major pungent ingredient found in the rhizome of ginger, has been reported to possess a strong antiinflammatory activity, which is considered to be closely associated with its cancer chemopreventive potential. [6]-Paradol, another pungent phenolic substance found in ginger and other Zingiberaceae plants, also has a vanilloid structure found in other chemopreventive phytochemicals including curcumin. In the present study, [6]-gingerol and [6]-paradol were found to exert inhibitory effects on the viability and DNA synthesis of human promyelocytic leukemia (HL-60) cells. The cytotoxic and antiproliferative effects of both compounds were associated with apoptotic cell death. The above results suggest that [6]-gingerol and [6]-paradol possess potential cytotoxic/cytostatic activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anticarcinogenic Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Catechols
  • Fatty Alcohols / chemistry
  • Fatty Alcohols / pharmacology*
  • Guaiacol / analogs & derivatives*
  • Guaiacol / chemistry
  • Guaiacol / pharmacology
  • HL-60 Cells
  • Humans


  • Anticarcinogenic Agents
  • Antineoplastic Agents
  • Catechols
  • Fatty Alcohols
  • zingerone
  • Guaiacol
  • gingerol