The latrophilin family: multiply spliced G protein-coupled receptors with differential tissue distribution

FEBS Lett. 1999 Jan 29;443(3):348-52. doi: 10.1016/s0014-5793(99)00005-8.

Abstract

Latrophilin is a brain-specific Ca2+-independent receptor of alpha-latrotoxin, a potent presynaptic neurotoxin. We now report the finding of two novel latrophilin homologues. All three latrophilins are unusual G protein-coupled receptors. They exhibit strong similarities within their lectin, olfactomedin and transmembrane domains but possess variable C-termini. Latrophilins have up to seven sites of alternative splicing; some splice variants contain an altered third cytoplasmic loop or a truncated cytoplasmic tail. Only latrophilin-1 binds alpha-latrotoxin; it is abundant in brain and is present in endocrine cells. Latrophilin-3 is also brain-specific, whereas latrophilin-2 is ubiquitous. Together, latrophilins form a novel family of heterogeneous G protein-coupled receptors with distinct tissue distribution and functions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing / genetics*
  • Amino Acid Sequence
  • Animals
  • Blotting, Northern
  • Brain / metabolism
  • Cattle
  • Cell Membrane / chemistry
  • Cloning, Molecular
  • Endocrine Glands / metabolism
  • Extracellular Matrix Proteins / chemistry
  • Extracellular Matrix Proteins / metabolism
  • GTP-Binding Proteins / physiology*
  • Gene Expression*
  • Gene Library
  • Glycoproteins / chemistry
  • Glycoproteins / metabolism
  • Liver / metabolism
  • Molecular Sequence Data
  • Organ Specificity
  • Protein Isoforms / chemistry
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Rats
  • Receptors, Peptide / chemistry
  • Receptors, Peptide / genetics*
  • Receptors, Peptide / isolation & purification
  • Receptors, Peptide / metabolism
  • Sequence Homology, Amino Acid
  • Spider Venoms / metabolism

Substances

  • Extracellular Matrix Proteins
  • Glycoproteins
  • Protein Isoforms
  • Receptors, Peptide
  • Spider Venoms
  • alpha-latrotoxin receptor
  • olfactomedin
  • alpha-latrotoxin
  • GTP-Binding Proteins

Associated data

  • GENBANK/AF111069
  • GENBANK/AF111070
  • GENBANK/AF111071
  • GENBANK/AF111072
  • GENBANK/AF111073
  • GENBANK/AF111074
  • GENBANK/AF111075
  • GENBANK/AF111076
  • GENBANK/AF111077
  • GENBANK/AF111078
  • GENBANK/AF111079
  • GENBANK/AF111080
  • GENBANK/AF111081
  • GENBANK/AF111082
  • GENBANK/AF111083
  • GENBANK/AF111084
  • GENBANK/AF111085
  • GENBANK/AF111086
  • GENBANK/AF111087
  • GENBANK/AF111088
  • GENBANK/AF111089
  • GENBANK/AF111090
  • GENBANK/AF111091
  • GENBANK/AF111092
  • GENBANK/AF111093
  • GENBANK/AF111094
  • GENBANK/AF111095
  • GENBANK/AF111096
  • GENBANK/AF111097
  • GENBANK/AF111098