Enhancement of anti-tumor immunity by injection of fibroblasts genetically engineered to produce IL-12 and to express CD70

Adv Exp Med Biol. 1998;451:353-7. doi: 10.1007/978-1-4615-5357-1_55.
No abstract available

MeSH terms

  • 3T3 Cells / transplantation
  • Adenocarcinoma / immunology
  • Adenocarcinoma / therapy*
  • Animals
  • Antigen-Presenting Cells / immunology
  • Antigens, CD*
  • CD27 Ligand
  • Female
  • Fibroblasts / transplantation*
  • Genetic Therapy / methods*
  • Immunotherapy / methods
  • Interleukin-12 / biosynthesis
  • Interleukin-12 / genetics*
  • Lymphocyte Culture Test, Mixed
  • Mammary Neoplasms, Experimental / immunology
  • Mammary Neoplasms, Experimental / therapy*
  • Membrane Proteins / biosynthesis
  • Membrane Proteins / genetics*
  • Mice
  • Mice, Inbred BALB C
  • Receptors, Immunologic / genetics
  • Spleen / immunology
  • T-Lymphocytes, Cytotoxic / immunology*
  • Transfection / methods
  • Tumor Cells, Cultured

Substances

  • Antigens, CD
  • CD27 Ligand
  • Cd70 protein, mouse
  • Membrane Proteins
  • Receptors, Immunologic
  • Interleukin-12