Cancer predictive value of cytogenetic markers used in occupational health surveillance programs

Recent Results Cancer Res. 1998;154:177-84. doi: 10.1007/978-3-642-46870-4_10.

Abstract

It has not previously been clear whether cytogenetic biomarkers in healthy subjects will predict cancer. Earlier analyses of a Nordic and an Italian cohort indicated predictivity for chromosomal aberrations (CAS) but not for sister chromatid exchanges (SCES). A pooled analysis of the updated cohorts, forming a joint study base of 5271 subjects, will now be performed, allowing a more solid evaluation. The importance of potential effect modifiers, such as gender, age at testing, and time since testing, will be evaluated using Poisson regression models. Two other potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers
  • Chromosome Aberrations*
  • Health Surveys*
  • Humans
  • Incidence
  • Micronuclei, Chromosome-Defective*
  • Neoplasms / epidemiology
  • Neoplasms / etiology*
  • Neoplasms / genetics
  • Occupational Health*
  • Sister Chromatid Exchange*

Substances

  • Biomarkers