Signal transduction by the receptor tyrosine kinase Ret

Recent Results Cancer Res. 1998;154:271-81. doi: 10.1007/978-3-642-46870-4_18.

Abstract

Ret is the receptor for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN). Defects in this receptor underlie several genetic syndromes. The receptor is a transmembrane tyrosine kinase which transduces Ret-mediated signaling to a variety of signaling pathways, most notably the Ras signaling pathway and the phosphatidylinositol-3 kinase pathway. These pathways are activated through the interaction of adaptor proteins to tyrosine phosphorylated receptor. The ultimate biological effects, depending on the cell type, include morphological changes in the cytoskeleton, cell scattering, proliferation, and differentiation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinases / physiology
  • Drosophila Proteins*
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • Humans
  • Mitogen-Activated Protein Kinase 1
  • Nerve Growth Factors / physiology
  • Nerve Tissue Proteins / physiology
  • Neurturin
  • Phosphatidylinositol 3-Kinases / physiology
  • Proto-Oncogene Proteins / chemistry
  • Proto-Oncogene Proteins / physiology*
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases / chemistry
  • Receptor Protein-Tyrosine Kinases / physiology*
  • Signal Transduction*

Substances

  • Drosophila Proteins
  • GDNF protein, human
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glial Cell Line-Derived Neurotrophic Factor Receptors
  • NRTN protein, human
  • Nerve Growth Factors
  • Nerve Tissue Proteins
  • Neurturin
  • Proto-Oncogene Proteins
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases
  • Ret protein, Drosophila
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Mitogen-Activated Protein Kinase 1