The role of diabetes mellitus in the aetiology of renal cell cancer

Diabetologia. 1999 Jan;42(1):107-12. doi: 10.1007/s001250051122.


To investigate the relation between diabetes mellitus and the risk of renal cell cancer we carried out a population-based retrospective cohort study. Patients identified in the Swedish Inpatient Register who were discharged from hospitals with a diagnosis of diabetes mellitus between 1965 and 1983 formed a cohort of 153852 patients (80005 women and 73847 men). The cohort members were followed up to 1989 by record linkage to three nation-wide registries. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were computed using age-specific sex-specific and period-specific incidence and mortality rates derived from the entire Swedish population. After exclusion of the first year of observation, a total of 267 incidences of renal cell cancer (ICD-7:180.0) occurred in diabetic patients compared with the 182.4 that had been expected. Increased risks were observed in both women (SIR = 1.7, 95% confidence interval, CI = 1.4-2.0) and men (SIR = 1.3; 95 % CI = 1.1-1.6) throughout the duration of follow-up (1-25 years). A higher risk was seen for kidney cancer (ICD-7:180) mortality (SMR = 1.9; 95% CI = 1.7-2.2, women; SMR 1.7, 95% CI = 1.4-1.9, men). In comparison with the general population, patients with diabetes mellitus have an increased risk of renal cell cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Aged
  • Carcinoma, Renal Cell / epidemiology*
  • Carcinoma, Renal Cell / etiology*
  • Carcinoma, Renal Cell / mortality
  • Cohort Studies
  • Confidence Intervals
  • Diabetes Complications*
  • Diabetes Mellitus / epidemiology
  • Female
  • Humans
  • Incidence
  • Inpatients
  • Kidney Neoplasms / epidemiology*
  • Kidney Neoplasms / etiology*
  • Kidney Neoplasms / mortality
  • Male
  • Middle Aged
  • Registries
  • Risk Factors
  • Sex Characteristics
  • Sweden / epidemiology