Intracerebroventricular injection of arginine-vasopressin V1 receptor antagonist attenuates the surge of luteinizing hormone and prolactin secretion in proestrous rats

Neurosci Lett. 1999 Jan 22;260(1):37-40. doi: 10.1016/s0304-3940(98)00940-9.

Abstract

In the present study, we examined the effect of arginine-vasopressin (AVP) V1 receptor antagonist ([Deamino-Pen1, Tyr(Me)2, Arg8]-vasopressin) injection (1 microg/2 microl saline) into the third ventricle in the proestrous rat on serum concentrations of luteinizing hormone (LH) and prolactin (PRL) which were determined between 1100 and 2100 h at 1-h intervals. Control rats were injected with 2 microl saline. The injection of AVP receptor antagonist at 1300 h resulted in significant decreases in both LH and PRL secretion compared to saline-injected rats. The present study provides evidence supporting our hypothesis that endogenous AVP plays a role in the induction of the surge of LH and PRL secretion as a stimulatory factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antidiuretic Hormone Receptor Antagonists*
  • Arginine Vasopressin / analogs & derivatives
  • Arginine Vasopressin / antagonists & inhibitors*
  • Arginine Vasopressin / pharmacology
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / metabolism
  • Female
  • Injections, Intraventricular
  • Luteinizing Hormone / metabolism*
  • Proestrus / drug effects*
  • Prolactin / metabolism*
  • Rats
  • Rats, Wistar

Substances

  • Antidiuretic Hormone Receptor Antagonists
  • Arginine Vasopressin
  • argipressin, deaminopenicillamine(1)-O-methyl-Tyr(2)-
  • Prolactin
  • Luteinizing Hormone