Mayaro virus disease: an emerging mosquito-borne zoonosis in tropical South America

Clin Infect Dis. 1999 Jan;28(1):67-73. doi: 10.1086/515070.


This report describes the clinical, laboratory, and epidemiological findings on 27 cases of Mayaro virus (MV) disease, an emerging mosquito-borne viral illness that is endemic in rural areas of tropical South America. MV disease is a nonfatal, dengue-like illness characterized by fever, chills, headache, eye pain, generalized myalgia, arthralgia, diarrhea, vomiting, and rash of 3-5 days' duration. Severe joint pain is a prominent feature of this illness; the arthralgia sometimes persists for months and can be quite incapacitating. Cases of two visitors from the United States, who developed MV disease during visits to eastern Peru, are reported. MV disease and dengue are difficult to differentiate clinically.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Distribution
  • Alphavirus / classification
  • Alphavirus / genetics
  • Alphavirus / immunology
  • Alphavirus / isolation & purification*
  • Alphavirus Infections / diagnosis*
  • Alphavirus Infections / epidemiology
  • Alphavirus Infections / virology
  • Animals
  • Antibodies, Viral / blood
  • Culicidae
  • DNA, Viral / analysis
  • Female
  • Humans
  • Insect Vectors
  • Middle Aged
  • Peru / epidemiology
  • Seasons
  • Sequence Analysis, DNA
  • Zoonoses


  • Antibodies, Viral
  • DNA, Viral