Management of a premature infant with moderate haemophilia A using recombinant factor VIII

Haemophilia. 1998 Nov;4(6):850-3. doi: 10.1046/j.1365-2516.1998.00201.x.

Abstract

The birth of a very premature infant with haemophilia A is a rare event. In this case report the problems posed in the management of a child with a factor VIII level of 0.03 IU mL-1 born at 28 weeks of gestation and weighing 1590 g are considered. The value of recombinant factor VIII, the pharmacokinetics of factor VIII in this situation and the importance of close cooperation between paediatricians and haematologists are discussed.

Publication types

  • Case Reports

MeSH terms

  • Factor VIII / administration & dosage*
  • Factor VIII / pharmacokinetics
  • Female
  • Hemophilia A / drug therapy*
  • Hemophilia A / genetics
  • Hemophilia A / physiopathology
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Male
  • Pregnancy
  • Pregnancy Complications, Hematologic*
  • Recombinant Proteins / administration & dosage
  • Recombinant Proteins / pharmacokinetics

Substances

  • Recombinant Proteins
  • Factor VIII