Bat feces as an indoor allergen

J Investig Allergol Clin Immunol. 1998 Nov-Dec;8(6):365-9.

Abstract

We have demonstrated in an animal model (specific IgG) as well as in atopic patients suffering from rhinitis/asthma (specific IgE) that bat feces have antigenic properties. A single peak with high glycoprotein content was obtained by chromatography, while SDS-PAGE revealed several proteins between 29 and 116 kDa which showed immune serum blotting at 43.6 and 66 kDa. Positive specific skin tests with bat feces and IgE-RAST anti-bat feces were detected in atopic patients living in tall buildings and old houses in Buenos Aires. As bat feces did not cross-react with bat epithelium, studies evaluating rat serum and epithelium and pigeon feces in order to analyze the role of bat serum proteins, such as IgA, are encouraged.

MeSH terms

  • Adult
  • Air Pollution, Indoor
  • Allergens / immunology*
  • Animals
  • Asthma / immunology
  • Chiroptera / immunology*
  • Electrophoresis, Polyacrylamide Gel
  • Feces / chemistry*
  • Female
  • Glycoproteins / immunology
  • Housing
  • Humans
  • Hypersensitivity, Immediate / immunology*
  • Immunoblotting
  • Immunoelectrophoresis
  • Male
  • Rabbits
  • Radioallergosorbent Test
  • Rats
  • Rhinitis, Allergic, Perennial / immunology
  • Skin Tests

Substances

  • Allergens
  • Glycoproteins