Side effects of triazolam in children

Pediatr Dent. Jan-Feb 1999;21(1):18-25.

Abstract

Purpose: This study examined the incidence of side effects occurring with three doses of orally administered triazolam in children undergoing restorative dental procedures.

Methods: Thirty children, aged 39-81 months, participated in the study. The children were pretested for gait ataxia, amnesia, visual acuity, stereoscopic depth perception, and diplopia during a screening session. In a subsequent appointment, children received one of three triazolam dosages (0.005, 0.015, and 0.030 mg/kg) prior to dental treatment. Dosage assignment was random and double blind. Each child received a single triazolam dosage. Tests for gait ataxia, amnesia, and visual disturbances were repeated following drug administration.

Results: The proportion of children experiencing ataxia, amnesia, and diplopia increased with increasing triazolam dosages. The 0.030-mg/kg triazolam dosage impaired visual acuity and stereoscopic depth perception.

Conclusion: Triazolam produces ataxia, amnesia, and diplopia in a dose-dependent manner in children.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Oral
  • Amnesia / chemically induced
  • Analysis of Variance
  • Anesthesia, Dental / adverse effects
  • Anesthesia, Dental / statistics & numerical data
  • Ataxia / chemically induced
  • Child
  • Child, Preschool
  • Dental Care for Children
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Female
  • Gait / drug effects
  • Humans
  • Hypnotics and Sedatives / administration & dosage
  • Hypnotics and Sedatives / adverse effects*
  • Male
  • Triazolam / administration & dosage
  • Triazolam / adverse effects*
  • Vision Disorders / chemically induced

Substances

  • Hypnotics and Sedatives
  • Triazolam