Optic nerve hypoplasia with posterior pituitary ectopia: male predominance and nonassociation with breech delivery

Am J Ophthalmol. 1999 Feb;127(2):238-9. doi: 10.1016/s0002-9394(98)00338-9.


Purpose: To determine whether posterior pituitary ectopia in children with optic nerve hypoplasia has a male predominance or an increased incidence of breech delivery.

Method: Retrospective analysis of 12 children with optic nerve hypoplasia and posterior pituitary ectopia.

Results: Eleven of 12 patients with posterior pituitary ectopia were boys. No child had a history of breech delivery. Two children had a history of breech positioning but were delivered by cesarean section.

Conclusion: Posterior pituitary ectopia with optic nerve hypoplasia shows a strong male predominance but no association with breech delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Arkansas / epidemiology
  • Breech Presentation*
  • Child
  • Child, Preschool
  • Female
  • Growth Hormone / deficiency
  • Humans
  • Hypopituitarism / diagnosis
  • Hypopituitarism / epidemiology
  • Hypopituitarism / etiology*
  • Incidence
  • Infant
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Male
  • Optic Nerve / abnormalities*
  • Optic Nerve / pathology
  • Pituitary Gland, Posterior / abnormalities*
  • Pituitary Gland, Posterior / pathology
  • Pituitary Hormones, Anterior / deficiency
  • Pregnancy
  • Retrospective Studies
  • Sex Distribution


  • Pituitary Hormones, Anterior
  • Growth Hormone