Analgesic-induced renal papillary necrosis in the Gunn rat: the comparative nephrotoxicity of aspirin and phenacetin

J Pathol. 1976 Nov;120(3):145-50. doi: 10.1002/path.1711200303.


Homozygous Gunn rats, mutant Wistars genetically lacking glucuronyl transferase, develop renal papillary necrosis after single oral doses of aspirin and of phenacetin. The lesion appears significantly more frequently with aspirin than phenacetin, and at lower doses. The model is a convenient one with which to study analgesic nephrotoxicity.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Aspirin / toxicity*
  • Dose-Response Relationship, Drug
  • Kidney / pathology
  • Kidney Papillary Necrosis / chemically induced*
  • Kidney Papillary Necrosis / pathology
  • Male
  • Phenacetin / toxicity*
  • Rats
  • Rats, Inbred Strains


  • Phenacetin
  • Aspirin