Immunogenetic aspects of nasopharyngeal carcinoma. IV. Increased risk in Chinese of nasopharyngeal carcinoma associated with a Chinese-related HLA profile (A2, Singapore 2)

J Natl Cancer Inst. 1976 Nov;57(5):977-80. doi: 10.1093/jnci/57.5.977.


The results of this study of 110 Singapore Chinese with nasopharyngeal carcinoma (NPC) and 91 controls confirmed the association between the occurrence of HLA antigen Singapore 2 (Sin2) and NPC in the Chinese population, and indicated that their increased risk for NPC was confined to the joint occurrence of Sin 2 and A2 antigens. These findings suggested that the genotype of importance in susceptibility to NPC is the A2-Sin 2 haplotype.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Asian Continental Ancestry Group*
  • Female
  • Genotype
  • HLA Antigens*
  • Histocompatibility Antigens*
  • Humans
  • Lymphocytes / immunology
  • Male
  • Nasopharyngeal Neoplasms / genetics*
  • Nasopharyngeal Neoplasms / immunology
  • Risk
  • Singapore


  • HLA Antigens
  • Histocompatibility Antigens