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Review
, 57 (1), 127-33

[Eradication Rate and Side Effect From a Point of View of Helicobacter Pylori Eradication of Peptic Ulcer Disease in Dual Therapy or New Triple Therapy]

[Article in Japanese]
Affiliations
  • PMID: 10036949
Review

[Eradication Rate and Side Effect From a Point of View of Helicobacter Pylori Eradication of Peptic Ulcer Disease in Dual Therapy or New Triple Therapy]

[Article in Japanese]
A Iwasaki. Nihon Rinsho.

Abstract

Eradication rate of Helicobacter pylori in dual therapy (omeprazole/amoxicillin) are reported in the range of 28-91%, side effect such as loose stool and skin reaction are reported 3.9-16.8%. In our study, eradication rate in dual therapy is 69.6% (lansoprazole/amoxicillin) and 74.0% (lansoprazole/clarithromycin). In triple therapy, eradication rate is 93.8% (lansoprazole/amoxicillin/clarithromycin), 94.4% (lansoprazole/amoxicillin/metronidazole) and 100.0% (lansoprazole/clarithromycin/metronidazole). There is no difference eradication rate between 1 week (89.2%) and 2 weeks (92.9%) regimen. In general, eradication rate of new triple therapy is effective in the range of 80-100%, and side effect are reported in 1.7-49%. However, Suzuki et al reported side effect decreased in new triple therapy adding mucosal protective agent.

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