From head to toes: the multiple facets of Sox proteins

Nucleic Acids Res. 1999 Mar 15;27(6):1409-20. doi: 10.1093/nar/27.6.1409.


Sox proteins belong to the HMG box superfamily of DNA-binding proteins and are found throughout the animal kingdom. They are involved in the regulation of such diverse developmental processes as germ layer formation, organ development and cell type specifi-cation. Hence, deletion or mutation of Sox proteins often results in developmental defects and congenital disease in humans. Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context. They exhibit a remarkable crosstalk and functional redundancy among each other.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA-Binding Proteins / classification
  • DNA-Binding Proteins / physiology*
  • Gene Expression Regulation, Developmental
  • High Mobility Group Proteins / classification
  • High Mobility Group Proteins / physiology*
  • Lens, Crystalline / embryology
  • Nervous System / embryology
  • Nuclear Proteins*
  • Sex Differentiation
  • Sex-Determining Region Y Protein
  • Transcription Factors*


  • DNA-Binding Proteins
  • High Mobility Group Proteins
  • Nuclear Proteins
  • Sex-Determining Region Y Protein
  • Transcription Factors