The association of anti-Ro52 autoantibodies with myositis and scleroderma autoantibodies

J Autoimmun. 1999 Mar;12(2):137-42. doi: 10.1006/jaut.1998.0265.


The presence of autoantibodies to the Ro52 protein in sera from patients with idiopathic inflammatory myopathies has recently been reported. These antibodies were found predominately in sera with the myositis-specific autoantibody anti-histidyl-tRNA synthetase (anti-Jo-1). In this report, we analysed sera from 216 patients to determine whether anti-Ro52 antibodies are associated with myositis autoantibodies other than anti-Jo-1. These included sera containing antibodies that recognize threonyl- or alanyl-tRNA synthetases, Mi-2, PM-Scl, signal recognition particle (SRP), as well as the systemic sclerosis-related antibodies anti-topoisomerase I (Scl-70) and anti-centromere. A high proportion of sera that contain anti-aminoacyl-tRNA synthetase antibodies, anti-SRP, or anti-PM-Scl antibodies were found to contain antibodies to the Ro52 protein. In contrast, in sera containing anti-Mi-2, anti-Scl-70 or anti-centromere antibodies, anti-Ro52 antibodies were absent or occurred infrequently. In addition, only one serum from 41 rheumatoid arthritis patients was positive for anti-Ro52 autoantibodies. These data indicate that anti-Ro52 antibodies are produced in particular subsets of myositis patients, and are not limited to sera with anti-Jo-1 antibodies.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acyl-tRNA Synthetases / immunology
  • Antibodies, Antinuclear / blood
  • Autoantibodies / blood*
  • Autoantigens / chemistry
  • Autoantigens / immunology*
  • Humans
  • Myositis / immunology*
  • RNA, Small Cytoplasmic*
  • Ribonucleoproteins / chemistry
  • Ribonucleoproteins / immunology*
  • Scleroderma, Systemic / immunology*


  • Antibodies, Antinuclear
  • Autoantibodies
  • Autoantigens
  • Jo-1 antibody
  • RNA, Small Cytoplasmic
  • RO60 protein, human
  • Ribonucleoproteins
  • SS-A antigen
  • Amino Acyl-tRNA Synthetases