Cytoplasmic dynein and dynactin in cell division and intracellular transport

Curr Opin Cell Biol. 1999 Feb;11(1):45-53. doi: 10.1016/s0955-0674(99)80006-4.


Since the initial discovery of cytoplasmic dynein, it has become apparent that this microtubule-based motor is involved in several cellular functions including cell division and intracellular transport. Another multisubunit complex, dynactin, may be required for most, if not all, cytoplasmic dynein-driven activities and may provide clues to dynein's functional diversity. Recent genetic and biochemical findings have illuminated the cellular roles of dynein and dynactin and provided insight into the functional mechanism of this complex motor.

Publication types

  • Review

MeSH terms

  • Anaphase
  • Animals
  • Aspergillus nidulans / metabolism
  • Biological Transport
  • Cell Division / physiology*
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism*
  • Dynactin Complex
  • Dyneins / metabolism*
  • Golgi Apparatus / metabolism
  • Humans
  • Kinetochores / metabolism
  • Microtubule-Associated Proteins / metabolism*
  • Saccharomyces cerevisiae / metabolism
  • Spindle Apparatus / metabolism


  • Dynactin Complex
  • Microtubule-Associated Proteins
  • Dyneins