Responses of CD8(+) T cells to intracellular bacteria

Curr Opin Immunol. 1999 Feb;11(1):89-93. doi: 10.1016/s0952-7915(99)80016-8.


Recent studies of CD8(+) T cell responses against intracellular bacteria have provided insights into the relevance of the exogenous and endogenous MHC class I presentation pathways during the priming and effector stages. The capacity of these organisms to deliver vaccine antigens, either as bacterial protein or as plasmid DNA expressed by host antigen-presenting cells, has been investigated. Ongoing studies of CD8(+) T cell effector functions suggest the existence of novel pathways of resistance to bacterial infection. These results, together with advances in our understanding of nonclassical MHC class I presentation, reveal the impact of pathogen biology on host immunity to infection.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Bacterial / immunology
  • Bacteria / immunology*
  • Bacterial Infections / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Humans


  • Antigens, Bacterial