C1q-binding proteins and C1q receptors

Curr Opin Immunol. 1999 Feb;11(1):42-6. doi: 10.1016/s0952-7915(99)80008-9.


Aggregated or immobilized complement C1q induces cellular responses in many different cell types. C1q-induced cellular responses may be involved in host defense and in protection against autoimmunity because C1q-deficient humans have infectious complications and a very high incidence of autoimmune disease. The search for the C1q receptor(s), which has been ongoing for 25 years, has led recently to the recognition that proteins identified as binding to C1q may be divided into two groups: C1q-binding molecules that are normally intracellular; and cell surface C1q receptors.

Publication types

  • Review

MeSH terms

  • Carrier Proteins*
  • Complement C1q / immunology*
  • Complement C1q / metabolism
  • Humans
  • Hyaluronan Receptors*
  • Immunity, Innate
  • Membrane Glycoproteins*
  • Mitochondrial Proteins
  • Proteins / immunology*
  • Proteins / metabolism
  • Receptors, Complement / immunology*
  • Receptors, Complement / metabolism


  • C1QBP protein, human
  • Carrier Proteins
  • Hyaluronan Receptors
  • Membrane Glycoproteins
  • Mitochondrial Proteins
  • Proteins
  • Receptors, Complement
  • c1q-binding proteins
  • complement 1q receptor
  • Complement C1q