Molecular and Cellular Biology of Pneumococcal Infection

Curr Opin Microbiol. 1999 Feb;2(1):35-9. doi: 10.1016/s1369-5274(99)80006-x.

Abstract

The complete pneumococcal genome sequence was released in November, 1997. This advance has been combined with new understanding of physiology and pathogenesis including characterization of a family of surface proteins adducted to choline, regulation of virulence, and the regulon for natural DNA transformation. These developments in our understanding of molecular and cellular biology of pneumococcal infection will allow the development of new vaccines and antibiotics against this community acquired pathogen.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Antigens, Bacterial / genetics
  • Antigens, Bacterial / immunology
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Choline / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Heat-Shock Proteins / genetics
  • Heat-Shock Proteins / metabolism
  • Humans
  • Mice
  • N-Acetylmuramoyl-L-alanine Amidase / genetics
  • Phenotype
  • Pneumococcal Infections / epidemiology
  • Pneumococcal Infections / microbiology*
  • Streptococcus pneumoniae / chemistry
  • Streptococcus pneumoniae / pathogenicity
  • Streptococcus pneumoniae / physiology*
  • Streptolysins / genetics
  • Virulence

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • CbpA protein, bacteria
  • DNA-Binding Proteins
  • Heat-Shock Proteins
  • Streptolysins
  • plY protein, Streptococcus pneumoniae
  • pneumococcal surface protein A
  • EJL amidase
  • N-Acetylmuramoyl-L-alanine Amidase
  • Choline