Virulence gene regulation by peptides in staphylococci and other Gram-positive bacteria

Curr Opin Microbiol. 1999 Feb;2(1):40-5. doi: 10.1016/s1369-5274(99)80007-1.


In staphylococci, autoinducing peptides activate agr. a global regulator of the expression of genes encoding virulence factors and other exoproteins. During the past year, there have been major advances in the structure-function analysis of these peptides and the regulation of a virulence factor by an autoinducing peptide in pneumococci has been demonstrated.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Bacterial Proteins / metabolism*
  • DNA Helicases / pharmacology
  • DNA-Binding Proteins*
  • Disease Models, Animal
  • Gene Expression Regulation, Bacterial
  • Mice
  • Mutation
  • Peptides, Cyclic
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Trans-Activators / pharmacology


  • AgrD protein, Staphylococcus
  • Bacterial Proteins
  • DNA-Binding Proteins
  • Peptides, Cyclic
  • Trans-Activators
  • rap protein, bacteria
  • replication initiator protein
  • DNA Helicases