Mechanism of Shigella Entry Into Epithelial Cells

Curr Opin Microbiol. 1999 Feb;2(1):51-5. doi: 10.1016/s1369-5274(99)80009-5.

Abstract

Shigella, the causative agent of bacillary dysentery, invades epithelial cells by reorganizing the cell cytoskeleton during bacterial entry. This entry process requires the Shigella Ipa proteins that are secreted by a type III secretion apparatus and that act in concert to fine tune cell responses. Actin polymerization at the site of entry is dependent on the IpaB and IpaC proteins, whereas IpaA further modulates cytoskeletal rearrangements by binding to vinculin.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Bacterial / metabolism*
  • Apoptosis
  • Bacterial Proteins / metabolism*
  • CHO Cells
  • Cricetinae
  • Cytoskeleton / physiology
  • Epithelial Cells / cytology
  • Epithelial Cells / microbiology*
  • GTP Phosphohydrolases / metabolism
  • Humans
  • Hyaluronan Receptors / metabolism
  • Integrins / metabolism
  • Shigella / pathogenicity
  • Shigella / physiology*
  • Vinculin / metabolism
  • Virulence

Substances

  • Antigens, Bacterial
  • Bacterial Proteins
  • Hyaluronan Receptors
  • Integrins
  • IpaA protein, Shigella flexneri
  • Vinculin
  • ipaB protein, Shigella
  • IpaC protein, Shigella
  • GTP Phosphohydrolases