The fundamentals of protein folding: bringing together theory and experiment

Curr Opin Struct Biol. 1999 Feb;9(1):92-101. doi: 10.1016/s0959-440x(99)80012-8.


Experimental and theoretical studies together are providing insights into the mechanism by which proteins fold. Our present knowledge of the essential aspects of the folding reaction is outlined and some approaches, both theoretical and experimental, that are being developed to obtain a more detailed understanding of this complex process are described.

Publication types

  • Review

MeSH terms

  • Models, Molecular
  • Protein Folding*
  • Surface Properties
  • Thermodynamics