Polyamine analogue-mediated cell cycle responses in human melanoma cells involves the p53, p21, Rb regulatory pathway

Biochem Soc Trans. 1998 Nov;26(4):609-14. doi: 10.1042/bst0260609.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetyltransferases / biosynthesis
  • Apoptosis / drug effects
  • Cell Cycle / drug effects*
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins / metabolism*
  • Enzyme Induction
  • Humans
  • Melanoma / enzymology
  • Melanoma / metabolism*
  • Melanoma / pathology
  • Retinoblastoma Protein / metabolism*
  • Spermine / analogs & derivatives*
  • Spermine / pharmacology
  • Tumor Cells, Cultured
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • CDKN1A protein, human
  • Cyclin-Dependent Kinase Inhibitor p21
  • Cyclins
  • Retinoblastoma Protein
  • Tumor Suppressor Protein p53
  • N(1),N(11)-diethylnorspermine
  • Spermine
  • Acetyltransferases
  • diamine N-acetyltransferase