Peripheral T cell lymphoma in a patient with common variable immunodeficiency disease: case report and literature review

Leuk Lymphoma. 1999 Feb;32(5-6):589-95. doi: 10.3109/10428199909058418.


This report documents the occurrence of a peripheral T cell lymphoma arising in the bone marrow and liver of a patient with common variable immunodeficiency disease. The T cell origin of this lymphoma was demonstrated by immunohistochemical phenotyping and gene rearrangement studies and was not associated with EBV infection of the lymphoma cells. The frequency and characteristics of lymphomas complicating CVID are reviewed.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Common Variable Immunodeficiency* / complications
  • Common Variable Immunodeficiency* / genetics
  • Common Variable Immunodeficiency* / pathology
  • Female
  • Humans
  • Lymphoma, T-Cell, Peripheral* / etiology
  • Lymphoma, T-Cell, Peripheral* / genetics
  • Lymphoma, T-Cell, Peripheral* / pathology