Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol

Pathology. 1976 Jul;8(3):179-84. doi: 10.3109/00313027609058995.


Cortical tubular necrosis induced by either aspirin (300 mg/kg) or oxyphenbutazone (444 mg/kg) was reduced if probenecid (300 mg/kg) was administered at the same time. The prior administration of aspirin (600 mg/kg) reduced the tubular necrosis that follows administration of oxyphenbutazone (444 mg/kg) alone, thus demonstrating that some degree of cross-tolerance between the two drugs occurs. Phenacetin pretreatment (597 mg/kg) was less effective, while paracetamol (503 mg/kg) was without effect in this regard. Those substances that reduced the oxyphenbutazone-induced cortical lesion also ameliorated the focal degenerative change in the lower nephron attributed to this drug. Oral administration of 2:4 dinitrophenol (20 mg/kg) led to only minor cortical tubular necrosis in a few animals.

MeSH terms

  • Acetaminophen / therapeutic use
  • Acute Kidney Injury / chemically induced*
  • Animals
  • Aspirin / therapeutic use
  • Aspirin / toxicity*
  • Dinitrophenols / toxicity*
  • Female
  • Kidney Tubular Necrosis, Acute / chemically induced*
  • Kidney Tubular Necrosis, Acute / prevention & control
  • Oxyphenbutazone / toxicity*
  • Phenacetin / therapeutic use
  • Probenecid / therapeutic use
  • Rats


  • Dinitrophenols
  • Acetaminophen
  • Phenacetin
  • Oxyphenbutazone
  • Probenecid
  • Aspirin