Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24

Genomics. 1999 Feb 1;55(3):341-4. doi: 10.1006/geno.1998.5650.


Conductin or Axil, an Axin homolog, plays an important role in the regulation of beta-catenin stability in the Wnt signaling pathway. To facilitate the molecular analysis of the human gene, we isolated the human homolog, AXIN2. The cDNA contains a 2529-bp open reading frame and encodes a putative protein of 843 amino acids. Compared with rat and mouse homologs, AXIN2 shows an overall 89% amino acid identity. Several functional domains in this protein are highly conserved including the GRS (95.9%), GSK-3beta (96.3%), Dsh (98%), and beta-catenin (89.9%) domains. Radiation hybrid mapping localized the AXIN2 gene to human chromosome 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Human AXIN2 is thus a very strong candidate involved in multiple tumor types.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Amino Acid Sequence
  • Animals
  • Axin Protein
  • Carrier Proteins*
  • Chromosomes, Human, Pair 17 / genetics*
  • Cloning, Molecular
  • Cytoskeletal Proteins / genetics*
  • DNA Primers
  • Humans
  • Molecular Sequence Data
  • Proteins / genetics*
  • Proto-Oncogene Proteins / genetics
  • Rats
  • Repressor Proteins*
  • Sequence Homology, Amino Acid
  • Signal Transduction
  • Trans-Activators*
  • Wnt Proteins
  • Zebrafish Proteins*
  • beta Catenin


  • AXIN2 protein, human
  • Adaptor Proteins, Signal Transducing
  • Axin Protein
  • Axin2 protein, rat
  • CTNNB1 protein, human
  • Carrier Proteins
  • Ctnnb1 protein, rat
  • Cytoskeletal Proteins
  • DNA Primers
  • Proteins
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Trans-Activators
  • Wnt Proteins
  • Zebrafish Proteins
  • beta Catenin

Associated data

  • GENBANK/AF078165