Nonoperative treatment of Dupuytren's disease

Hand Clin. 1999 Feb;15(1):97-107, vii.


Many nonoperative therapies have been investigated for the treatment of Dupuytren's disease. These include needle fasciotomy, continuous slow skeletal traction, radiation, dimethyl sulfoxide, vitamin E, allopurinol, physical therapy, ultrasound therapy, steroid injections, radiation, interferon, splinting, and enzymatic fasciotomy. Most of these therapies have not proven to be clinically useful. However, recent investigation of enzymatic fasciotomy using collagenase injection has shown encouraging results.

Publication types

  • Review

MeSH terms

  • Collagenases / therapeutic use
  • Dupuytren Contracture / diagnostic imaging
  • Dupuytren Contracture / therapy*
  • Fasciotomy
  • Humans
  • Metacarpophalangeal Joint / diagnostic imaging
  • Ultrasonography


  • Collagenases