Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR

Genomics. 1999 Mar 1;56(2):217-20. doi: 10.1006/geno.1998.5705.


Human p21/SIIR is a novel Ser/Arg/Pro-rich nuclear phosphoprotein that is 48% similar to transcription factor SII and modulates transcription in a promoter context-dependent fashion. We have obtained the complete sequence of TCEAL1, the gene that codes for p21/SIIR. This gene consists of three exons and two introns with the entire coding sequence in exon III. Tissue-specific expression patterns of TCEAL1 by Northern blot analysis showed the presence of an approximately 1.2-kb transcript in all normal human tissues examined, and heart and skeletal muscle contained an additional transcript of approximately 7 kb. Expression was lowest in hematopoietic cells of both normal and tumor origin. TCEAL1 was mapped to human chromosome Xq22.1 by fluorescence in situ hybridization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chickens
  • Chromosome Banding
  • Chromosome Mapping
  • DNA / chemistry
  • DNA / genetics
  • DNA-Binding Proteins / genetics*
  • Exons
  • Female
  • Genes / genetics*
  • HeLa Cells
  • Humans
  • In Situ Hybridization, Fluorescence
  • Introns
  • Male
  • Mice
  • Molecular Sequence Data
  • Nuclear Proteins / genetics*
  • Phosphoproteins / genetics*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Sequence Analysis, DNA
  • Tissue Distribution
  • Transcription Factors / genetics*
  • Tumor Cells, Cultured
  • X Chromosome / genetics*


  • DNA-Binding Proteins
  • Nuclear Proteins
  • Phosphoproteins
  • RNA, Messenger
  • TCEAL1 protein, human
  • Transcription Factors
  • DNA

Associated data

  • GENBANK/AF095906