Salivary immunoglobulin A levels of persons who have stopped smoking

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Feb;87(2):170-3. doi: 10.1016/s1079-2104(99)70268-4.


Objective: The aim of this study was to determine salivary immunoglobulin A levels in people who stopped smoking for at least 2 weeks. Salivary immunoglobulin A is a primary antibody at mucosal surfaces.

Study design: Salivary immunoglobulin A levels of each of 20 subjects were determined on 3 occasions: first, while the subject was still smoking; second, 7 days after cessation of smoking; third, on the 14th day after cessation. Two control groups (with 20 people in each group) were also used: the members of the first had never smoked, and the members of the second were current smokers. Results were analyzed through use of a repeated-measures analysis of variance and the t test.

Results: Seven days after cessation of the smoking habit, a transient decrease in salivary immunoglobulin A levels was observed. However, within 14 days the levels returned to normal.

Conclusions: Salivary immunoglobulin A levels transiently decrease in people who have stopped smoking for 7 days, but they recover to normal values within 2 weeks after cessation of the habit.

MeSH terms

  • Adult
  • Analysis of Variance
  • Case-Control Studies
  • Gingivitis / immunology
  • Humans
  • Immunity, Mucosal
  • Immunoglobulin A, Secretory / analysis*
  • Oral Ulcer / immunology
  • Saliva / immunology*
  • Smoking / immunology
  • Smoking Cessation*


  • Immunoglobulin A, Secretory