Seroprevalence study of herpes simplex virus type 2 among pregnant women in Germany using a type-specific enzyme immunoassay

Eur J Clin Microbiol Infect Dis. 1998 Dec;17(12):870-2. doi: 10.1007/s100960050210.


In a German seroepidemiological study to determine the proportion of pregnant women infected with herpes simplex virus type 2 (HSV-2) and at risk of transmitting the infection to the newborn during delivery, IgG antibodies to HSV-2 in 1999 sera collected from pregnant women in 1996-1997 were measured using an automated type-specific enzyme immunoassay (Cobas Core HSV-2 IgG EIA; Roche Diagnostics, Switzerland). The seroprevalence of HSV-2 was 8.9%, and control studies with a type-common HSV assay measuring antibodies to HSV-1 and HSV-2 revealed that 20.7% of pregnant women were seronegative for HSV antibodies and are therefore at risk of acquiring primary genital HSV infection of either type.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Viral / blood*
  • Child
  • Female
  • Germany / epidemiology
  • Herpes Genitalis / diagnosis*
  • Herpes Genitalis / epidemiology*
  • Herpes Genitalis / transmission
  • Herpesvirus 2, Human / classification
  • Herpesvirus 2, Human / immunology
  • Herpesvirus 2, Human / isolation & purification*
  • Humans
  • Immunoenzyme Techniques
  • Immunoglobulin G / blood
  • Infant
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Male
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis*
  • Pregnancy Complications, Infectious / epidemiology*
  • Seroepidemiologic Studies


  • Antibodies, Viral
  • Immunoglobulin G