IgM paraproteinemia in a patient with primary lateral sclerosis

Neuromuscul Disord. 1999 Jan;9(1):38-40. doi: 10.1016/s0960-8966(98)00089-3.


Primary lateral sclerosis is an uncommon, distinct clinical entity. We report a patient with primary lateral sclerosis in whom investigations revealed an IgM monoclonal gammopathy, raised CSF protein and persistently high ESR. A number of reports suggest that lymphoproliferative disorders, paraproteinemia and clinico-pathological syndromes mimicking motor neuron diseases may be associated. We discuss the clinical features noted in our patient in relation to these reports, and the possible pathogenetic mechanisms.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amyotrophic Lateral Sclerosis / blood
  • Amyotrophic Lateral Sclerosis / metabolism*
  • Amyotrophic Lateral Sclerosis / physiopathology
  • Blood Sedimentation
  • Cerebrospinal Fluid Proteins / metabolism
  • Electromyography
  • Humans
  • Immunoglobulin M / blood*
  • Male
  • Paraproteinemias / blood
  • Paraproteins / metabolism*


  • Cerebrospinal Fluid Proteins
  • Immunoglobulin M
  • Paraproteins