Alpha-interferon and isoprinosine in adult-onset subacute sclerosing panencephalitis

J Neurol Sci. 1999 Jan 1;162(1):62-4. doi: 10.1016/s0022-510x(98)00302-5.


We report eight patients with adult-onset subacute sclerosing panencephalitis (SSPE), of which, four were treated with oral isoprinosine and four with intraventricular alpha-interferon plus oral isoprinosine. One of the four patients treated with oral isoprinosine died within two months, and the disease progressed in three patients. Of the four patients treated with oral isoprinosine plus intraventricular alpha-interferon, one showed mild progression, one remission, and the remaining two showed stabilization. The group of patients is relatively small, but our results suggest that treatment with oral isoprinosine plus alpha-interferon is effective for SSPE.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Age of Onset
  • Antiviral Agents / therapeutic use*
  • Drug Therapy, Combination
  • Electroencephalography
  • Follow-Up Studies
  • Humans
  • Injections, Intraventricular
  • Inosine Pranobex / therapeutic use*
  • Interferon Type I / therapeutic use*
  • Magnetic Resonance Imaging
  • Male
  • Prospective Studies
  • Recombinant Proteins
  • Subacute Sclerosing Panencephalitis / drug therapy*
  • Treatment Outcome


  • Antiviral Agents
  • Interferon Type I
  • Recombinant Proteins
  • Inosine Pranobex