RNA sorting in Xenopus oocytes and embryos

FASEB J. 1999 Mar;13(3):435-45. doi: 10.1096/fasebj.13.3.435.

Abstract

Cytoplasmic localization of mRNA molecules has emerged as a powerful mechanism for generating spatially restricted gene expression. This process is an important contributor to cell polarity in both somatic cells and oocytes, and can provide the basis for patterning during embryonic development. In vertebrates, this phenomenon is perhaps best documented in the frog, Xenopus laevis, where polarity along the animal-vegetal axis coincides with the localization of numerous mRNA molecules. Research over the last several years has made exciting progress toward understanding the molecular mechanisms underlying cytoplasmic mRNA localization.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Glycoproteins / metabolism
  • Oocytes / metabolism*
  • RNA / metabolism*
  • Transforming Growth Factor beta / metabolism
  • Xenopus Proteins
  • Xenopus laevis / embryology
  • Xenopus laevis / genetics*

Substances

  • GDF1 protein, Xenopus
  • Glycoproteins
  • Transforming Growth Factor beta
  • Xenopus Proteins
  • RNA