Feeding response to central orexins

Brain Res. 1999 Mar 13;821(2):535-8. doi: 10.1016/s0006-8993(99)01136-1.


Orexin A and orexin B were microinjected into the perifornical hypothalamus (PFH), lateral hypothalamus (LH), hypothalamic paraventricular nucleus (PVN), and ventral tegmental area (VTA) of male Sprague-Dawley rats. Orexin B (15 nmol) was also injected into the lateral cerebral ventricle (i.c.v.). Orexin A (>/=500 pmol) stimulated feeding in the PFH and LH, but not in the VTA or PVN. Orexin B stimulated feeding only when injected i.c.v.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Carrier Proteins / pharmacology*
  • Eating / drug effects
  • Feeding Behavior / drug effects*
  • Hypothalamic Area, Lateral / drug effects
  • Hypothalamic Area, Lateral / physiology*
  • Injections, Intraventricular
  • Intracellular Signaling Peptides and Proteins*
  • Male
  • Neuropeptides / pharmacology*
  • Orexins
  • Paraventricular Hypothalamic Nucleus / drug effects
  • Paraventricular Hypothalamic Nucleus / physiology
  • Rats
  • Rats, Sprague-Dawley
  • Ventral Tegmental Area / drug effects
  • Ventral Tegmental Area / physiology


  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • Neuropeptides
  • Orexins