[Nobel prize in Medicine and Physiology 1998 for the discovery of the role of nitric oxide as a signalling molecule]

Ned Tijdschr Geneeskd. 1998 Dec 26;142(52):2828-30.
[Article in Dutch]


The Nobel Prize for Medicine and Physiology 1998 was awarded to three American pharmacologists: Robert F.Furchgott, Louis J. Ignarro and Ferrid Murad for their work on nitric oxide as a signalling molecule in the cardiovascular system. This discovery is a classical case of serendipity. NO is an endothelium-derived factor which mediates local vasodilation. It protects the vascular system against atherosclerosis by various effects on leukocytes and vascular permeability. NO appears to be a universal signalling molecule in the body, involved in the inflammatory response, apoptosis and neurotransmission. Its biochemistry is closely linked to that of oxygen radicals.

Publication types

  • Biography
  • English Abstract
  • Historical Article

MeSH terms

  • Cardiovascular Physiological Phenomena
  • History, 20th Century
  • Humans
  • Nitric Oxide / physiology*
  • Nobel Prize*
  • United States


  • Nitric Oxide

Personal name as subject

  • R F Furchgott
  • L J Ignarro
  • F Murad