Modulation of drug metabolism in infectious and inflammatory diseases

Drug Metab Rev. 1999 Feb;31(1):29-41. doi: 10.1081/dmr-100101906.

Abstract

During inflammation, expression of various P450 genes is modulated differentially. Both the downregulation of some P450s and the induction of others may be the result of a complex interaction involving inflammatory cytokines, stress hormones, and metabolic perturbations. Our results suggest that NO is not an important mediator for the downregulation of CYP2C11 in rat liver.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aryl Hydrocarbon Hydroxylases*
  • Communicable Diseases / enzymology*
  • Communicable Diseases / genetics
  • Cytochrome P-450 Enzyme System / genetics
  • Cytochrome P-450 Enzyme System / metabolism*
  • Down-Regulation / drug effects
  • Glucocorticoids / pharmacology
  • Humans
  • Inflammation / enzymology*
  • Inflammation / genetics
  • Nitric Oxide / physiology*
  • Pharmaceutical Preparations / metabolism*
  • Pharmacokinetics
  • Steroid 16-alpha-Hydroxylase*
  • Steroid Hydroxylases / genetics
  • Stress, Physiological / enzymology
  • Stress, Physiological / genetics*

Substances

  • Glucocorticoids
  • Pharmaceutical Preparations
  • Nitric Oxide
  • Cytochrome P-450 Enzyme System
  • Steroid Hydroxylases
  • Aryl Hydrocarbon Hydroxylases
  • Steroid 16-alpha-Hydroxylase