P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues

Drug Metab Rev. 1999 Feb;31(1):205-34. doi: 10.1081/dmr-100101915.

Abstract

Historically, there has been intense interest in P450 metabolic oxidation, peroxidation, and reduction of xenobiotics. More recently, there has been a growing appreciation for the role of P450s in the oxidation of lipophilic endobiotics, such as bile acids, fat-soluble vitamins, and eicosanoids. This review details the emerging CYP2J subfamily of P450s and their role as catalysts of arachidonic acid metabolism.

Publication types

  • Review

MeSH terms

  • Animals
  • Arachidonic Acid / metabolism*
  • Biotransformation
  • Chromosome Mapping
  • Cytochrome P-450 Enzyme System / classification
  • Cytochrome P-450 Enzyme System / genetics*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Cytochrome P-450 Enzyme System / physiology
  • Humans
  • Oxygenases / genetics
  • Oxygenases / metabolism*

Substances

  • Arachidonic Acid
  • Cytochrome P-450 Enzyme System
  • Oxygenases
  • arachidonate epoxygenase