T-cell turnover in vivo and the role of cytokines

Immunol Lett. 1999 Jan;65(1-2):21-5. doi: 10.1016/s0165-2478(98)00119-9.


In addition to responding to specific antigen, CD8+ T-cells with a memory (CD44hi) phenotype undergo bystander proliferation when exposed to certain cytokines, notably type I interferons (IFN I), in vivo; such proliferation does not require T-cell receptor ligation. Since IFN I is unable to induce proliferation of purified CD44hi CD8+ cells in vitro, stimulation of these cells in vivo may reflect IFN I-dependent release of other cytokines. Evidence is presented that IFN I induces macrophages to synthesize IL-15 mRNA and that, at the protein level, IL-15 causes selective stimulation of CD44hi CD8+ (but not CD4+) cells, both in vitro and in vivo. This finding raises the possibility that synthesis of IL-15 during infection may induce bystander proliferation of memory-phenotype CD8+ cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • CD8-Positive T-Lymphocytes / classification
  • CD8-Positive T-Lymphocytes / immunology*
  • Cytokines / physiology*
  • Hyaluronan Receptors / immunology
  • Hyaluronan Receptors / metabolism
  • Immunologic Memory
  • Interferon Type I / physiology
  • Lymphocyte Activation
  • Mice


  • Cytokines
  • Hyaluronan Receptors
  • Interferon Type I