Cyclins and breast cancer

Breast Cancer Res Treat. 1998;52(1-3):17-28. doi: 10.1023/a:1006102916060.


Cyclins are regulatory subunits for cyclin dependent kinases in the coordination of the cell cycle. Cyclins can also serve non-cell cycle functions, such as the transactivation of estrogen receptor by cyclin D. Evidence for the participation of the G1 cyclins D and E in breast cancer is summarized, including transgenic and knockout mice, transfections, and expression patterns in cohort studies. Overexpression of cyclin D has been reported in ductal carcinoma in situ (DCIS), and similar overexpression of cyclin E is suggested. Strategies to reduce cyclin expression are discussed as potential prevention efforts.

Publication types

  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / chemistry*
  • Breast Neoplasms / prevention & control
  • Cyclin D1 / analysis
  • Cyclin D1 / physiology
  • Cyclin E / analysis
  • Cyclin E / physiology
  • Cyclins / analysis*
  • Cyclins / genetics
  • Cyclins / physiology
  • Female
  • Humans
  • Mice
  • Precancerous Conditions / chemistry
  • Retinoids / pharmacology
  • Tamoxifen / pharmacology


  • Cyclin E
  • Cyclins
  • Retinoids
  • Tamoxifen
  • Cyclin D1