How bacteria initiate inflammation: aspects of the emerging story

Curr Opin Microbiol. 1998 Feb;1(1):43-8. doi: 10.1016/s1369-5274(98)80141-0.


Recent studies have shown that bacteria possess an array of proinflammatory molecules in addition to the extensively studied lipopolysaccharide and superantigens. These bacterial molecules include soluble and membrane-associated inducers of cytokine release, inducers of host cell apoptosis, and immunostimulatory DNA. There is therefore much greater diversity in the class of molecules and mechanisms by which bacteria engage the host immune system than previously appreciated.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Apoptosis
  • Bacteria / immunology
  • Bacteria / pathogenicity*
  • Bacterial Infections / immunology*
  • DNA, Bacterial / immunology
  • Humans
  • Inflammation / immunology
  • Inflammation / physiopathology*
  • Interleukin-8 / biosynthesis
  • Lipopolysaccharides / immunology


  • DNA, Bacterial
  • Interleukin-8
  • Lipopolysaccharides