Signal transduction by MAP kinase cascades in budding yeast

Curr Opin Microbiol. 1998 Apr;1(2):175-82. doi: 10.1016/s1369-5274(98)80008-8.


Budding yeast contain at least four distinct MAPK (mitogen activated protein kinase) cascades that transduce a variety of intracellular signals: mating-pheromone response, pseudohyphal/invasive growth, cell wall integrity, and high osmolarity adaptation. Although each MAPK cascade contains a conserved set of three protein kinases, the upstream activation mechanisms for these cascades are diverse, including a trimeric G protein, monomeric small G proteins, and a prokaryotic-like two-component system. Recently, it became apparent that there is extensive sharing of signaling elements among the MAPK pathways; however, little undesirable cross-talk occurs between various cascades. The formation of multi-protein signaling complexes is probably centrally important for this insulation of individual MAPK cascades.

Publication types

  • Review

MeSH terms

  • Calcium-Calmodulin-Dependent Protein Kinases / genetics
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal*
  • Mating Factor
  • Osmolar Concentration
  • Peptides / metabolism
  • Phosphoprotein Phosphatases / metabolism
  • Protein Kinase C / metabolism
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism*
  • Signal Transduction*


  • Fungal Proteins
  • Peptides
  • Mating Factor
  • Protein Kinase C
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Phosphoprotein Phosphatases