Initiation of bacterial development

Curr Opin Microbiol. 1998 Apr;1(2):170-4. doi: 10.1016/s1369-5274(98)80007-6.


The discovery of a mitotic apparatus in bacteria has led to significant recent progress being made in understanding the regulatory connections between the cell cycle, chromosome segregation and the onset of developmental processes in sporulation. The control of developmental transcription by antagonism between protein kinase and protein phosphatase reached a new level of complexity with the discovery of peptide inhibitors of protein phosphatases that cycle between the interior and exterior cell surface as information messengers. New mechanisms of developmental regulation are being uncovered in a variety of microbial systems.

Publication types

  • Review

MeSH terms

  • 4-Butyrolactone / analogs & derivatives
  • 4-Butyrolactone / metabolism
  • Bacteria / genetics*
  • Bacteria / growth & development*
  • Bacterial Physiological Phenomena
  • Cell Cycle
  • GTP Phosphohydrolases / metabolism
  • Gene Expression Regulation, Bacterial
  • Phosphoprotein Phosphatases / metabolism
  • Protein Kinase Inhibitors
  • Protein Kinases / metabolism
  • Spores, Bacterial / physiology


  • Protein Kinase Inhibitors
  • A-factor (Streptomyces)
  • Protein Kinases
  • Phosphoprotein Phosphatases
  • GTP Phosphohydrolases
  • 4-Butyrolactone