Abstract
The virulence of Cryptococcus neoformans isolates with high and low extracellular proteolytic activity was investigated in mice. No consistent relationship between proteolytic activity and virulence was observed, but isolates derived from one strain were shown to elicit different inflammatory responses.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antigens, Fungal / immunology
-
Cryptococcosis / immunology*
-
Cryptococcus neoformans / classification*
-
Cryptococcus neoformans / immunology
-
Cryptococcus neoformans / pathogenicity*
-
Mice
-
Mice, Inbred A
-
Pneumonia / immunology
-
Serotyping
-
Virulence