A murine model of renal abscess formation

Clin Diagn Lab Immunol. 1999 Mar;6(2):273-5. doi: 10.1128/CDLI.6.2.273-275.1999.

Abstract

We developed a murine model of kidney abscess by direct renal injection of either Escherichia coli (1 x 10(6) to 7 x 10(6) organisms) or sterile medium. Bacterial infection produced renal abscesses, bacteremia, and late-onset leukocytosis in all animals. Controls were unaffected. This model may be useful for the study of various sequelae of kidney infection.

MeSH terms

  • Abscess / immunology
  • Abscess / microbiology*
  • Abscess / physiopathology
  • Animals
  • Bacteremia / immunology
  • Bacteremia / microbiology
  • Bacteremia / physiopathology
  • Disease Models, Animal*
  • Escherichia coli Infections / immunology
  • Escherichia coli Infections / physiopathology*
  • Female
  • Kidney Diseases / immunology
  • Kidney Diseases / microbiology*
  • Kidney Diseases / physiopathology
  • Leukocytosis / microbiology
  • Mice
  • Mice, Inbred Strains*
  • Neutrophils / microbiology