[Retinal hemodynamics in patients with normal pressure glaucoma. Quantification with digital laser scanning fluorescein angiography]

Ophthalmologe. 1999 Jan;96(1):24-9. doi: 10.1007/s003470050371.
[Article in German]


Chronic ischemia of the retina and the optic nerve head seems of importance especially in patients with normal-tension glaucoma (NTG). The purpose of this study was to examine the retinal hemodynamics in patients with NTG.

Patients: Twenty-five patients with NTG were examined (3 weeks washout period) in this study (age 58 +/- 16 years). The arteriovenous passage (AVP) time and arterial and venous diameters from scanning laser fluorescein angiograms were evaluated by means of digital image analysis.

Results: The AVP time in patients with NTG (2.78 +/- 1.1 s) was significantly prolonged (P < 0.0001) compared with healthy subjects (1.58 +/- 0.4 s). No significant correlation was found between arterial and venous diameters, intraocular pressure, blood pressure or calculated perfusion pressure and retinal arteriovenous passage time.

Conclusion: Patients with NTG showed prolonged retinal passage, which could cause chronic hypoxia. This prolongation of circulation is not correlated with any of the clinical parameters. Thus, a circulatory defect might be a primary factor in the pathogenesis of NTG.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiography, Digital Subtraction / instrumentation*
  • Blood Flow Velocity / physiology
  • Chronic Disease
  • Equipment Design
  • Fluorescein Angiography / instrumentation*
  • Hemodynamics / physiology*
  • Humans
  • Image Processing, Computer-Assisted / instrumentation
  • Ischemia / diagnosis*
  • Ocular Hypertension / diagnosis*
  • Optic Disk / blood supply*
  • Reference Values
  • Sensitivity and Specificity