In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene

Eur J Immunogenet. 1999 Feb;26(1):1-3. doi: 10.1046/j.1365-2370.1999.00122.x.


The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-gamma (IFN-gamma) production. In vitro production of IFN-gamma showed a significant correlation with the presence of allele #2.

MeSH terms

  • Alleles
  • Chromosomes, Human, Pair 12 / genetics
  • Dinucleotide Repeats / genetics*
  • Enzyme-Linked Immunosorbent Assay
  • Genetic Testing
  • Genotype
  • Humans
  • Interferon-gamma / genetics*
  • Molecular Sequence Data
  • Polymorphism, Genetic


  • Interferon-gamma

Associated data

  • GENBANK/AF031844