Escherichia coli mutator genes

Trends Microbiol. 1999 Jan;7(1):29-36. doi: 10.1016/s0966-842x(98)01424-3.


The isolation and characterization of Escherichia coli mutator genes have led to a better understanding of DNA replication fidelity mechanisms and to the discovery of important DNA repair pathways and their relationship to spontaneous mutagenesis. Mutator strains in a population of cells can be beneficial in that they allow rapid selection of variants during periods of stress, such as drug exposure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • DNA Repair
  • Escherichia coli / genetics*
  • Escherichia coli / growth & development
  • Escherichia coli / pathogenicity
  • Escherichia coli Infections / microbiology
  • Genes, Bacterial*
  • Humans
  • Mutagenesis*