Crossmodal associative memory representations in rodent orbitofrontal cortex

Neuron. 1999 Feb;22(2):349-59. doi: 10.1016/s0896-6273(00)81095-8.

Abstract

Firing patterns of neurons in the orbitofrontal cortex (OF) were analyzed in rats trained to perform a task that encouraged incidental associations between distinct odors and the places where their occurrence was detected. Many of the neurons fired differentially when the animals were at a particular location or sampled particular odors. Furthermore, a substantial fraction of the cells exhibited odor-specific firing patterns prior to odor presentation, when the animal arrived at a location associated with that odor. These findings suggest that neurons in the OF encode cross-modal associations between odors and locations within long-term memory.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Association Learning / physiology*
  • Behavior, Animal / physiology
  • Brain Mapping*
  • Electrophysiology
  • Frontal Lobe / cytology
  • Frontal Lobe / physiology*
  • Male
  • Memory / physiology*
  • Neurons / physiology
  • Odorants
  • Olfactory Pathways / cytology
  • Olfactory Pathways / physiology
  • Rats
  • Rats, Long-Evans
  • Space Perception / physiology